Neuroactive steroids, compositions, and uses thereof

A method for treating a CNS-related disorder in a human subject in need thereof comprising administering to the human subject a therapeutically effective amount of a) a compound of Formula (I) or a pharmaceutically acceptable salt thereof or b) a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, or heterocyclyl;
• each of R2a and R2b is independently hydrogen, C1-C6 alkyl, halo, cyano, —ORA, or —NRBRC, or
• R2a and R2b together with the carbon atom to which they are attached form a ring;
• R3 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, or —C(O)NRBRC;
• R4 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, or —ORA;
• represents a single or double bond, wherein when one is a double bond, the other is a single bond;
• wherein when the between —CR6 and —CR5aR5b is a double bond, then one of R5a or R5b is absent;
• and
• when one of the is a double bond, R6 is absent;
• each of R5a and R5b is independently absent, hydrogen, C1-C6 alkyl, or halo;
• R6 is absent or hydrogen;
• Z is —CR7aR7b—, wherein each of R7a and R7b is independently hydrogen or C1-C6 alkyl, or R7a and R7b, together with the carbon atom to which they are attached, form a ring;
• RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
• each of RB and RC is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a ring.