Aryl imidazoles for treatment of cancer
AssigneeAptose Biosciences Inc.
InventorsWilliam G. RICE, Stephen H. HOWELL, Cheng-Yu TSAI
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Abstract
The present invention relates to a method of preventing, reducing, or treating cancer in a subject, comprising administering a therapeutically effective amount of or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate (including metal chelates, such as iron, zinc and others) thereof to the subject, wherein the subject has a mutation in a DNA repair gene.
Claims35
A method of preventing, reducing or treating cancer in a subject, comprising administering a therapeutically effective amount of Compound I:
- or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate thereof to the subject;
- wherein the subject has a mutation in a DNA repair gene.
A method for killing cancer cells, comprising contacting said cells with a therapeutically effective amount of Compound I
- or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate thereof.
A method for inducing cell cycle arrest in cancer cells, comprising contacting said cells with a therapeutically effective amount of Compound I
- or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate thereof.
A method of preventing, reducing or treating cancer in a subject, comprising administering a therapeutically effective amount of one or more molecules of
- in complex with one or more metal atoms, wherein the subject has a mutation in a DNA repair gene.
Dependencies are inferred from the claim text.