Nitrogen-containing tricyclic compounds and uses thereof in medicine

A compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof,

• wherein:
• T is —NH—, —O—, —S—, —C(═O)— or —CH2—;
• each of X and Y is independently a bond, —O—, —S(═O)t—, —NRx—, —CRyRz— or —C(═O)—, or —X—Y— is —CHRh—CHRk— or —CRy═CRz—;
• each Rx is independently hydrogen, deuterium, alkyl, aminoalkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, halo-substituted aryl or arylalkyl;
• each Ry and Rz is independently hydrogen, deuterium, F, Cl, Br, I, hydroxy, amino, nitro, cyano, alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, alkylamino, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, halo-substituted aryl or arylalkyl;
• or Ry and Rz together with the same carbon atom to which they are attached, independently and optionally form a cycloalkane ring or a heterocyclic ring, and wherein the cycloalkane ring and heterocyclic ring is independently and optionally substituted with substituents selected from F, Cl, Br, I, hydroxy, amino, nitro, cyano, methyl, ethyl, isopropyl and trifluoromethyl;
• each of Rh and Rk is independently hydrogen, deuterium, F, Cl, Br, I, hydroxy, amino, nitro, cyano, methyl, ethyl, isopropyl or trifluoromethyl;
• or Rh and Rk, together with the carbon atoms to which they are attached, form a cycloalkane ring or a heterocyclic ring, wherein the cycloalkane ring and heterocyclic ring is independently and optionally substituted with substituents selected from F, Cl, Br, I, hydroxy, amino, nitro, cyano, methyl, ethyl, isopropyl and trifluoromethyl;
• each of Ra and Rb is independently hydrogen, deuterium or C1-3 alkyl;
• each Rc is independently hydrogen, deuterium, F, Cl, Br, I, oxo, hydroxy, amino, nitro, cyano, methyl, ethyl, n-propyl, isopropyl, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxymethyl, aminomethyl, methylamino, dimethylamino, methoxymethyl, isopropoxymethyl, vinyl, ethynyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, tetrahydropyranyl, morpholinyl, thiomorpholinyl, phenyl, thiazolyl, thienyl, oxazolyl, triazolyl, tetrazolyl, pyridinyl, pyrimidinyl, —COOH, —C(═O)O—C1-3 alkyl, —C(═O)NHS(═O)2—C1-3 alkyl, —C(═O)NHS(═O)2-phenyl, —C(═O)NH—C1-3 alkylene-S(═O)2OH, —C(═O)NH—C1-3 alkylene-C(═O)OH, —S(═O)2NH2, —S(═O)2OH, —S(═O)2—C1-3 alkyl, —C(═O)NH2 or —C(═O)N(CH3)2;
• each R1 is independently hydrogen, deuterium, F, Cl, Br, I, hydroxy, amino, nitro, cyano, alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxy, alkylamino, haloalkoxy, alkoxyalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkoxy, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, halo-substituted aryl, arylalkyl, heteroaryl, -L1-C(═O)OR8, -L1-S(═O)tR9, —O-L2-C(═O)OR8, —O-L2-S(═O)tR9, —C(═O)NR10R11, —C(═O)N(R10)S(═O)2R9, —C(═NR10)NR10R11, —C(═O)N(R10)-L3-S(═O)2OR8, —C(═O)N(R10)C(═O)OR8 or —C(═O)N(R10)-L3-C(═O)OR8;
• or two adjacent R1, together with the ring atoms to which they are attached, independently and optionally form a carbocyclic ring, heterocyclic ring, aromatic ring or heteroaromatic ring, and wherein each R1 is independently and optionally substituted with one or more R12;
• each R8 is independently hydrogen, deuterium, alkyl, aminoalkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl or aryl;
• each R9 is independently hydrogen, deuterium, hydroxy, amino, alkyl, aminoalkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl or —NR10R11;
• each R10 and R11 is independently hydrogen, deuterium, alkyl, aminoalkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl or aryl;
• or R10 and R11, together with the nitrogen atom to which they are attached, independently and optionally form a heterocyclic ring or heteroaromatic ring;
• each R12 is independently hydrogen, deuterium, F, Cl, Br, I, oxo, hydroxy, amino, nitro, cyano, alkyl, haloalkyl, alkoxy, alkylamino, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl;
• each L1 is independently a bond, —NH—, —C(═O)—, C1-3 alkylene, C2-4 alkenylene or C2-4 alkynylene;
• each L2 is independently C1-3 alkylene, C2-4 alkenylene or C2-4 alkynylene;
• each L3 is independently a bond or C1-3 alkylene;
• Z is
• each L is independently a bond, —O—, —S—, —NH—, —CH2—, —CH2—CH2—, —O—CH2—, —O—CH2—, —O—CH2—CH2— or —CH2—O—CH2—;
• each R2, R3, R4, R5 and R6 is independently hydrogen, deuterium, F, Cl, Br, I, hydroxy, amino, nitro, cyano, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy or C1-3 haloalkoxy;
• each R7 is independently hydrogen, deuterium, F, Cl, Br, I, hydroxy, amino, nitro, cyano, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkoxy-C1-6 alkyl, C3-6 cycloalkyl or C2-6 heterocyclyl, and wherein the C3-6 cycloalkyl and C2-6 heterocyclyl is independently and optionally substituted with substituents selected from F, Cl, Br, I, hydroxy, amino, nitro and cyano;
• m is 0, 1, 2, 3 or 4;
• n is 0, 1 or 2;
• and
• each t is independently 0, 1 or 2;
• with the proviso that a compound having formula (I) is not: