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US 2019/0169187 A1Published application
S1pr2 antagonists and uses therefor
AssigneeDalhousie University
InventorsChristopher McMaster, Gordon Simms
Life of this patent
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Abstract
Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are (Z)-3-((2,6-dichloropyridin-4-yl)amino)-3-(((4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)methyl)amino)acrylonitrile and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.
Claims20
A compound of formula (XI):
- or a pharmaceutically-acceptable salt thereof,
- wherein:
- G is CR10 or NR11, wherein R10 and R11 are each independently selected from the group consisting of H, C1-C4 alkyl, and benzyl;
- Rx and Ry are independently selected from the group consisting of H, C1-C4 alkyl, and benzyl;
- or Rx and Ry are joined to form a 5- or 6-membered heterocycloalkyl ring;
- and,
- the cyano group is in the (Z) or (E) configuration.
4 more elements
Dependencies are inferred from the claim text.