Back to results
US 2019/0169182 A1Published application
Novel therapeutic agents for the treatment of hbv infection
AssigneeNewave Pharmaceutical Inc.
InventorsYi Chen, Yan Lou
Life of this patent
Estimating the term…
Abstract
The disclosure includes compounds of Formula (I) wherein Z1, Z2, Z3, X, R1, R2, R3, R4, R5, R6, and R7 are defined herein. Also disclosed is a method for treating HBV infection.
Claims15
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is
A compound of Formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt, stereoisomer, solvate, polymorph or tautomer of said compound of Formula (I) or N-oxide thereof:
- wherein
- R1 is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, halo, nitro, oxo, cyano, —(CH2)pRa, —ORa, —SRa, —NH(CH2)pRa, —C(O)Ra, —S(O)Ra, —SO2Ra, —C(O)ORa, —OC(O)Ra, —NRbRc, —P(O)RbRc, —C(O)N(Rb)Rc, —N(Rb)C(O)Rc, —SO2N(Rb)Rc, or —N(Rb)SO2Rc, in which said alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl is optionally subsitiuted with one or more Rd;
- R5 is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, —(CH2)pRa, —C(O)Ra, —S(O)Ra, —SO2Ra, —C(O)ORa, —C(O)N(Rb)Rc, —SO2N(Rb)Rc, in which said alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl is optionally subsitiuted with one or more Rd;
- each of p, and q, independently, is 0, 1, 2, 3, 4, 5, 6, 7, or 8;
- and
- Ra, Rb, Rc and Rd, independently, is H, D, alkyl, alkenyl, alkynyl, halo, cyano, amine, nitro, hydroxy, C(O)NHOH, alkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylamino, alkylamino, oxo, halo-alkylamino, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl.
3 more elements
Dependencies are inferred from the claim text.