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US 2019/0169172 A1Published application
bis-Pyridazine Compounds and Their Use in Treating Cancer
AssigneesAstraZeneca AB, Cancer Research Technology Limited
InventorMaurice Raymond Verschoyle Finlay
Life of this patent
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Abstract
A compound of Formula (I): or a pharmaceutically where R1 can be hydro, methoxy, difluoromethoxy or trifluoromethoxy; R2 can be hydro, methoxy, trifluoromethoxy or trifluoromethyl; and R3 can be hydro or methoxy. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
Claims11
A method for treating cancer in a warm-blooded animal in need of such treatment, which comprises administering to said warm-blooded animal a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically where:
- R1 is hydro, methoxy, difluoromethoxy or trifluoromethoxy;
- R2 is hydro, methoxy, trifluoromethoxy or trifluoromethyl;
- and
- R3 is hydro or methoxy.
2 more elements
11-15. (canceled)
Dependencies are inferred from the claim text.