US 2019/0169168 A1Published application

Inhibitors of trpc6

AssigneesBoehringer Ingelheim International GmbH, Hydra Biosciences, Inc.

InventorsThierry Bouyssou, Dirk Gottschling, Niklas Heine, Lana Louise Smith Keenan, Michael D. Lowe, Hossein Razavi, Christopher Ronald Sarko, Simon Surprenant, Hidenori Takahashi, Michael Robert Turner, Xinyuan Wu

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Abstract

The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Claims12

Dependent claims

A compound selected from the group consisting of any one of compounds selected from the group consisting of:

[4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone,
[4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-(4-methoxy-5-phenoxy-pyridin-2-yl)-methanone,
[4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone,
[4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethyl-phenoxy)-pyridin-2-yl]-methanone,
[4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-methoxy-phenoxy)-pyridin-2-yl]-methanone,
[4-(6-Amino-4-ethoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(phenoxy)-pyridin-2-yl]-methanone,
(6-Amino-4-ethoxy-3′,4′,5′,6′-tetrahydro-2′H-[3,4′]bipyridinyl-1′-yl)-[5-(4-trifluoromethyl-phenoxy)-4-methoxy-pyridin-2-yl]methanone, and
6-(1-{4-Methoxy-5-[4-(trifluoromethyl)phenoxy]pyridine-2-carbonyl}piperidin-4-yl)-5-methylpyridazin-3-amine,
or a pharmaceutically acceptable salt thereof.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/170,178Filed 25 Oct 2018
Priority: 27 Oct 2017
Published: 6 Jun 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
A61K 31/45
Non condensed piperidines, e.g. piperocaine: having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
A61K 31/501
Pyridazines; Hydrogenated pyridazines: not condensed and containing further heterocyclic rings
C07D 213/04
Having three double bonds between ring members or between ring members and non-ring members: having no bond between the ring nitrogen atom and a…

Family

Application62/577,883Us provisional application · filed 27 Oct 2017
Application62/628,313Us provisional application · filed 9 Feb 2018
US 10,889,568 B2Related patent
US 2019/0169168 A1This patent

From the US filing history. Foreign family members aren’t listed.

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