Heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsJun FUJIMOTO, Xin LIU, Osamu KURASAWA, Terufumi TAKAGI, Douglas Robert CARY, Hiroshi BANNO, Yasutomi ASANO, Takuto KOJIMA
Life of this patent
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Abstract
Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
Claims14
A compound represented by the formula (I):
- wherein
- ring A is the formula:
- wherein ring B is an optionally further substituted 6-membered aromatic ring;
- two of X1, X2 and X3 are carbon atoms and the remaining one is a carbon atom or a nitrogen atom;
- R1 is a halogen atom, optionally halogenated methyl, or a hydroxy group optionally substituted by optionally halogenated methyl;
- R2 is a substituent, or the formula:
- wherein ring C is an optionally further substituted 6-membered aromatic ring;
- ring D is an optionally further substituted 5- to 7-membered ring;
- one of X4 and X5 is a carbon atom, and the other one is a carbon atom or a nitrogen atom;
- X6 is a hydrogen atom or a halogen atom;
- X7 is a halogen atom;
- ring E is an optionally further substituted nitrogen-containing 6-membered aromatic ring;
- X8 is a carbon atom or a nitrogen atom;
- X9 is a carbon atom or a nitrogen atom;
- and
- X10 is a hydrogen atom or an optionally substituted amino group, or
- X9 and X10 are bonded to each other to form an optionally substituted ring,
- or a salt thereof.
N-(3-((2-Aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide or a salt thereof.
5-Chloro-N-(2,4-difluoro-3-((2-((trans-4-hydroxycyclohexyl)amino)pyrimidin-5-yl)ethynyl)phenyl)-2-methoxypyridine-3-sulfonamide or a salt thereof.
2,5-Dichloro-N-(2,4-difluoro-3-((2-(((2R)-1-hydroxypropan-2-yl)amino)pyrimidin-5-yl)ethynyl)phenyl)-3-(hydroxymethyl)benzenesulfonamide or a salt thereof.
Dependencies are inferred from the claim text.