Benzazepine compounds, conjugates, and uses thereof

A conjugate represented by the formula:

• (D-L31-8 Antibody, wherein Antibody is an antibody construct, L3 is a linker moiety, and D is a compound represented by the structure of Formula (IIB):
• or a pharmaceutically acceptable salt thereof, wherein:
• L10 is selected from —C(O)—, and —C(O)N(R10)—*, wherein * represents where L10 is bound to R5—;
• L2 is selected from —C(O)— and —C(O)N(R10)—;
• R1 and R2 are independently selected from hydrogen;
• and C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• R4 is selected from:
• OR10, —N(R10)2, —C(O)N(R10)2, —C(O)R10, —C(O)OR10, —S(O)R10, and —S(O)2R10;
• and
• C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• and
• C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
• R5 is selected from unsaturated C4-8 carbocycle;
• bicyclic carbocycle;
• and fused 5-5, fused 5-6, and fused 6-6 bicyclic heterocycle, wherein R5 is optionally substituted and wherein substituents are independently selected at each occurrence from:
• halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• and
• C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• and
• C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
• R10 is independently selected at each occurrence from:
• hydrogen, —NH2, —C(O)OCH2C6H5;
• and
• C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, ═O, ═S, —C(O)OCH2C6H5, —NHC(O)OCH2C6H5, C1-10 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, 3- to 12-membered heterocycle, and haloalkyl;
• R20, R21, R22, and R23 are independently selected from hydrogen, halogen, OR10, —SR10, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl;
• and
• R24 and R25 are independently selected from hydrogen, halogen, —OR10, —SR10, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl;
• or R24 and R25 taken together form an optionally substituted saturated C3-7 carbocycle.