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US 2019/0169163 A1Published application
Quinoline derivative and use thereof
OwnerJianming Yininventor
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Abstract
Provided are a novel quinoline derivative, or a pharmaceutically acceptable salt, a hydrate, or a metabolite formed by metabolism in any form thereof, and use thereof in preparing a medicine for preventing and/or treating indications associated with angiogenesis. The quinoline derivative is an ideal and high-efficiency VEGFR inhibitor, and is able to be used to treat or prevent tumour growth and other metastasis growth diseases associated with angiogenesis.
Claims14
A quinoline derivative having a structure represented by Formula (I), or a pharmaceutically acceptable salt, a hydrate, or a metabolite formed by metabolism in any form thereof,
- wherein:
- R1 is R5 or NHR5, wherein R5 is selected from cycloalkyl, heterocyclic and substituted heterocyclic;
- R2 is selected from hydrogen, halogen, hydroxy, alkoxy and cyano;
- R3 and R4 are independently selected from OR6, C(O)NH2 and C(O)NHR6, wherein R6 is C1-C6 alkyl or halogenated alkyl;
- X is selected from NH and O;
- non-exchangeable hydrogen is unsubstituted, or partially or fully substituted by deuterium in the quinoline derivative having the structure represented by Formula (I), or the pharmaceutically acceptable salt, the hydrate, or the metabolite formed by metabolism in any form thereof.
3 more elements
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(canceled)
Dependencies are inferred from the claim text.