Ido1 inhibitor and preparation method and application thereof

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,

• wherein
• D is O, S or —S(═O)—;
• L is selected from a single bond, or selected from the group consisting of —C1-10 alkyl- group, —C3-6 cycloalkyl- group, —C3-6 cycloalkyl-C1-3 alkyl- group, -phenyl-group, 3- to 6-membered heterocycloalkyl- group, and 3- to 6-membered heterocycloalkyl-C1-3 alkyl- group, one or more of which are optionally substituted by 1, 2, or 3 R groups;
• R1 is selected from the group consisting of H, F, Cl, Br, I, OH, and NH2, or selected from the group consisting of C1-6 alkyl group, C3-6 cycloalkyl group, C1-6 heteroalkyl group, N,N-bis(C1-6 alkyl)amino group, 3- to 6-membered heterocycloalkyl group, C2-6 alkenyl group, phenyl group, 5- to 9-membered heteroaryl group,
• one or more of which are optionally substituted by 1, 2, or 3 R groups;
• R2 is OH or CN;
• R3, R4, and R5 are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, and NH2, or selected from the group consisting of C1-6 alkyl group, C3-6 cycloalkyl group, C1-6 heteroalkyl group, N,N-bis(C1-6 alkyl)amino group, and 3- to 6-membered heterocycloalkyl group, one or more of which are optionally substituted by 1, 2, or 3 R groups;
• R is selected from the group consisting of H, F, Cl, Br, I, OH, CN, and NH2, or selected from the group consisting of C1-6 alkyl group, C1-6 heteroalkyl group, N,N-bis(C1-6 alkyl)amino group, C3-6 cycloalkyl group, C2-6 alkenyl group, phenyl group, and thienyl group, one or more of which are optionally substituted by 1, 2, or 3 R′ groups;
• R′ is selected from the group consisting of F, Cl, Br, I, OH, CN, and NH2;
• “hetero” moieties in the -3- to 6-membered heterocycloalkyl, the -3- to 6-membered heterocycloalkyl-C1-3 alkyl-, the C1-6 heteroalkyl, the 3- to 6-membered heterocycloalkyl, or the 5- to 9-membered heteroaryl groups are each independently selected from the group consisting of —C(═O)NH—, —NH—, —S(═O)2NH—, —S(═O)NH—, N, —O—, —S—, ═O, ═S, —C(═O)O—, —C(═O)—, —C(═S)—, —S(═O)—, —S(═O)2—, —NHC(═O)NH—, —NHC(═S)NH—, and —H2P(═O)—NH— groups;
• and
• in any of above cases, number of heteroatom or heteroatom group is each independently selected from 1, 2 or 3.