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US 2019/0169138 A1Published application
Small molecule regulators of mitochondrial fusion and methods of use thereof
AssigneeWahington University
InventorsGerald W. Dorn, II, James Janetka
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Abstract
Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.
Claims4
A compound of formula (I):
- wherein, R1 is selected from the group consistina of
- R2 is selected from the group consisting of
- R3 is selected from the group consisting of hydrogen (H) and C1-8 alkyl;
- R4 is selected form the group consisting of hydrogen (H) and C1-8 alkyl;
- A is a SO, SO2;
- X is N;
- Y is N;
- and
- Z is a linker group selected from the group consisting of a bond or C1-6 alkyl.
6 more elements
Dependencies are inferred from the claim text.