US 2019/0169133 A1 · METHOD FOR MANUFACTURING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND INTERMEDIATE OF SAME

Abstract

An object of the present invention is to provide a method for industrially manufacturing a nitrogen-containing heterocyclic compound which shows excellent FLT3 inhibitory activity and is useful as a pharmaceutical active ingredient of pharmaceutical products. The present invention provides a manufacturing method of a compound represented by General Formula [14] or a salt thereof (in the formula, R1 represents a C1-6 alkyl group which may be substituted; and R8 represents a leaving group or the like).

Claims3

Dependent claims

A compound represented by General Formula [14] or a salt thereof:

wherein in General Formula [14], R1 represents a C1-6 alkyl group which may be substituted;
and R8 represents a chlorine atom, a hexamethylenetetraminium group, or a group represented by General Formula [4a]:
wherein in General Formula [4a], R2a represents a C1-6 alkoxycarbonyl group;
R3a represents a C1-6 alkoxycarbonyl group;
and * represents a binding position.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/272,263Filed 11 Feb 2019

Priority

JP 2015-14103415 Jul 2015

Published

6 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 239/48
Two or more oxygen, sulphur or nitrogen atoms: two nitrogen atoms
A61P 35/00
Antineoplastic agents
A61P 35/02
Antineoplastic agents: specific for leukemia
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00

Family

Application15/867,122Division · filed 10 Jan 2018

Application16/272,263Division

Application15/867,122Continuation

US 10,435,377 B2Related patent

US 10,562,862 B2Related patent

US 2018/0127382 A1Published application

US 2019/0169133 A1This patent

From the US filing history. Foreign family members aren’t listed.

Method for manufacturing nitrogen-containing heterocyclic compound and intermediate of same

Life of this patent

Method for manufacturing nitrogen-containing heterocyclic compound and intermediate of same

Life of this patent

Abstract

Claims3