Hyper Efficient Separations Device
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsMark Hayes, Claire Crowther, Paul Jones
Life of this patent
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Abstract
The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.
Claims27
A hyper-resolution insulator-based dielectrophoresis device for separating an analyte from a fluid, the device comprising:
- a fluid flow channel disposed on a substrate, the fluid flow channel being defined by a first wall, a second wall spaced from the first wall, at least one fluid inlet, and at least one fluid outlet, the first wall including an insulating flow structure extending toward the second wall thereby defining a constriction in the fluid flow channel between the first wall and the second wall, the insulating flow structure comprising a base section and a plurality of projections extending from the base section toward the second wall;
- electrodes in electrical communication with the at least one fluid inlet and the at least one fluid outlet of the fluid flow channel, wherein the electrodes are positioned to generate a spatially non-uniform electric field across the insulating flow structure of the fluid flow channel to exert a dielectrophoretic force on particles suspended in the fluid within the fluid flow chamber, and
- a power supply connected to each of the electrodes to generate an electric field within the fluid flow channel.
A multi-length scale structure for use in an insulator-based dielectrophoresis device for separating at least one analyte from a fluid, the device including a fluid flow channel disposed on a substrate, the fluid flow channel being defined by a first wall, and a second wall spaced from the first wall, the multi-length scale structure comprising:
- an insulating flow structure extending from the first wall toward the second wall thereby defining a constriction in the fluid flow channel between the first wall and the second wall, the insulating flow structure comprising a base section and a plurality of projections extending from the base section toward the second wall.
Dependencies are inferred from the claim text.