Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction
AssigneesLivaNova USA, Inc., East Tennessee State University
InventorsImad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Abstract
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
Claims20
A neurostimulator adapted to deliver a stimulation signal to a patient, said stimulation signal comprising an ON time and an OFF time, the neurostimulator comprising:
- a control system comprising a processor configured to:
- activate the neurostimulator to deliver the stimulation signal;
- during the OFF time of the stimulation signal, acquire a baseline signal comprising a baseline heart rate from a heart rate sensor;
- during the ON time of the stimulation signal, acquire a response signal comprising a heart rate response from the heart rate sensor;
- and
- change an intensity of the stimulation signal, based on the baseline signal and the response signal, to cause a transition heart rate response in the patient, the transition heart rate response being between tachycardia and bradycardia and comprising a heart rate change between the baseline heart rate and the heart rate response that is less than a predefined threshold.
A method of operating a neurostimulator adapted to deliver a stimulation signal to a patient, said stimulation signal comprising an ON time and an OFF time, the method comprising:
- activating the neurostimulator to deliver the stimulation signal;
- during the OFF time of the stimulation signal, acquiring a baseline signal comprising a baseline heart rate from a heart rate sensor;
- during the ON time of the stimulation signal, acquiring a response signal comprising a heart rate response from the heart rate sensor;
- and
- changing an intensity of the stimulation signal, based on the baseline signal and the response signal, to cause a transition heart rate response in the patient, the transition heart rate response between tachycardia and bradycardia and comprising a heart rate change between the baseline heart rate and the heart rate response that is less than a predefined threshold.
Dependencies are inferred from the claim text.