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AssigneeAssociation for the Advancement of Tissue Engineering and Cell Based Technologies & Therapie
InventorsCristiana RODRIGUES DE CARVALHO, João Pedro BEBIANO E COSTA, Viviana PINTO RIBEIRO, Joana Catarina DA SILVA CORREIA DE OLIVEIRA, Joaquim Miguel ANTUNES DE OLIVEIRA, Rui Luís GONÇALVES DOS REIS
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The present disclosure relates to a silk fibroin tubular conduit, a new methodology for obtaining said silk fibroin tubular conduit, and respective uses. The tubular conduit of the present disclosure can be used in treatment of diseases that involve the repair and/or regeneration of tissues, nerves or bone. In particular, the tubular conduit can be used for peripheral nerve regeneration.
A tubular conduit comprising an enzymatically cross-linked silk fibroin hydrogel, wherein said tubular conduit is predominantly β-sheet conformation and comprises a porosity up to 70% and a pore size up to 30 μm.
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A composition comprising a silk fibroin hydrogel enzymatically cross-linked with horseradish peroxidase and hydrogen peroxide, for use in medicine or in veterinary,
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Dependencies are inferred from the claim text.