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US 2019/0167839 A1Published application
Absorbable in situ gel-forming system, method of making and use thereof
OwnerShalaby W. Shalaby, Jason Olbrich +1inventors
InventorsShalaby W. Shalaby, Jason Olbrich, Joel T. Corbett
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Abstract
An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
Claims21
1-32. (canceled)
An in situ gel-forming composition, comprising:
- one or more absorbable polymers;
- and
- a solvent selected from the group consisting of N-methyl-2-pyrrolidone (NMP), polyethylene glycol (PEG), dimethyl sulfoxide (DMSO) and mixtures thereof, wherein said composition is an injectable liquid at a temperature in the range of about 18° C. to about 37° C. and forms a hydrogel or semi-solid mass on contact with an aqueous environment;
- wherein
- the one or more absorbable polymers comprise a molecular chain having a X-Y-X or (X-Y)n structure, wherein X represents a relatively hydrophobic polyester block and Y represents a relatively hydrophilic block;
- and wherein
- the X-Y-X or (X-Y)n structure is formed by grafting hydrophobic X blocks from monomers selected from the group consisting of glycolide, lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate or combinations thereof, to hydrophilic Y blocks selected from the group consisting of polyoxyethylene, poly(oxyethylene-b-oxypropylene), polypeptide polyalkylene oxamate, polysaccharide, derivatives thereof, and liquid, high molecular weight polyether glycols interlinked with an oxalate or succinate functionalities in linear or branched form.
4 more elements
Dependencies are inferred from the claim text.