US 2019/0167838 A1 · PHOSPHORYLATED POLY (ESTER-UREA) BASED DEGRADABLE BONE ADHESIVES

Abstract

In various aspects, the present invention provides a degradable and resorbable novel phosphate functionalized amino acid-based poly(ester urea) adhesive and related methods for its synthesis and use. These adhesives are formed from phosphate functionalized PEU polymers and copolymers crosslinked using one or more divalent metal crosslinking agents. The phosphate functionalized amino acid-based poly(ester urea) adhesives of various embodiments of the present invention have been found particularly effective in bonding bone to either bone or metal and have demonstrated adhesive strengths on bone samples that were significant and comparable to commercially available poly(methyl methacrylate) bone cement.

Claims20

Dependent claims

A poly(ester urea) (PEU) based adhesive comprising:

a PEU polymer backbone having one or more side chains comprising a phosphate group;
and
a crosslinking agent comprising a divalent metal salt.

Dependencies are inferred from the claim text.

Facts

Application

16/095,718Filed 25 Apr 2017

Priority

28 Apr 2016

Published

6 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61L 24/0042
Use of materials characterised by their function or physical properties: materials resorbable by the body
A61L 24/046
Containing macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C08K 3/16
Use of inorganic substances as compounding ingredients: halogen-containing compounds
C08L 75/02
Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers: polyureas

Phosphorylated poly (ester-urea) based degradable bone adhesives

Life of this patent

Phosphorylated poly (ester-urea) based degradable bone adhesives

Life of this patent

Abstract

Claims20