Novel aryl ethene derivative and pharmaceutical composition containing same as active ingredient

A pharmaceutical composition for treating thyroid cancer, comprising:

• the arylethene derivative represented by the following Chemical Formula 1:
• wherein
• L is (C6-C20)arylene, (C3-C20)heteroarylene, or (C3-C20)fused heterocycle;
• R1 is (C3-C20)heterocycloalkyl, (C3-C20)heteroaryl, —O—(CH2)m—R11, —(CH2)m—R12, —NH—(CH2)m—R13, —NHCO—(CH2)n—R14, or —SiR16R17—(CH2)m—R15;
• R11 to R15 are independently of one another (C3-C20)heterocycloalkyl;
• R16 and R17 are independently of each other (C1-C20)alkyl;
• m is an integer of 1 to 3;
• and
• n is an integer of 0 or 1;
• Ar is (C6-C20)aryl or (C3-C20)heteroaryl, in which the aryl or heteroaryl of Ar may be further substituted by one or more selected from the group consisting of hydroxy, halogen, (C1-C20)alkyl, halo(C1-C20)alkyl, (C1-C20)alkoxy, nitro, cyano, —NR21R22, (C1-C20)alkylcarbonyloxy, (C1-C20)alkylcarbonylamino, guanidino, —SO2—R23, and —OSO2—R24;
• R21 and R22 are independently of each other hydrogen, (C1-C20)alkylsulfonyl, or (C3-C20)cycloalkylsulfonyl;
• R23 and R24 are independently of each other (C1-C20)alkyl, halo(C1-C20)alkyl, or (C3-C20)cycloalkyl;
• R2 is hydroxy, halogen, (C1-C20)alkylcarbonyloxy, or (C1-C20)alkylsulfonyloxy;
• the heterocycloalkyl or heteroaryl of R1 and the heterocycloalkyl of R11 to R15 may be further substituted by one or more selected from the group consisting of (C1-C20)alkyl, (C3-C20)cycloalkyl, (C2-C20)alkenyl, amidino, (C1-C20)alkoxycarbonyl, hydroxy, hydroxy(C1-C20)alkyl, and di(C1-C20)alkylamino(C1-C20)alkyl;
• and
• the heterocycloalkyl and heteroaryl contains one or more heteroatoms selected from the group consisting of N, O and S, and the heterocycloalkyl is a saturated or unsaturated mono-, bi-, or spirocycle having a carbon atom or nitrogen atom in a ring as a binding site,
• or a prodrug, solvate, stereoisomer, or pharmaceutically acceptable salt thereof, as an effective component, and a pharmaceutically acceptable carrier, and being used in combination of radioactive iodine.