Methods for preventing or treating fibrotic diseases

Abstract

The present invention provides methods for preventing or treating a fibrotic disease in a subject. In some embodiments, the fibrotic disease is fatty liver disease, non-alcoholic fatty liver disease, or non-alcoholic steatohepatitis. In particular aspects, the methods comprise administering an inhibitor of Shc gene expression to achieve genetic suppression of Shc activity in the subject. In other aspects, the methods comprise administering a peptide, peptoid, or peptide-peptoid hybrid inhibitor of Shc to achieve pharmacological suppression of Shc protein activity in the subject.

Dependencies are inferred from the claim text.