US 2019/0167810 A1 · EXOSOMES COMPRISING THERAPEUTIC POLYPEPTIDES

Abstract

The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.

Claims22

Dependent claims

An extracellular vesicle (EV) comprising at least one polypeptide construct comprising:

(i) at least one polypeptide of interest (PoI);
(ii) at least one exosomal polypeptide;
and,
(iii) a polypeptide-based release system,
wherein the polypeptide-based release system releases the at least one PoI from the at least one exosomal polypeptide upon endogenous activation.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/304,580Filed 25 May 2017

Priority

GB 1609216.525 May 2016

Published

6 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification40 codes

A61K 47/6901
The conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit: conjugates being…
A61K 48/0008
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy:…
A61K 9/127
Dispersions; Emulsions: synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 38/47
Hydrolases: acting on glycosyl compounds , e.g. cellulases, lactases

Exosomes comprising therapeutic polypeptides

Life of this patent

Exosomes comprising therapeutic polypeptides

Life of this patent

Abstract

Claims22