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US 2019/0167804 A1Published application
Glucocorticoid receptor agonist and immunoconjugates thereof
AssigneeAbbVie Inc.
InventorsAdrian Hobson, Michael McPherson, Wendy Waegell, Christian Goess, Axel Hernandez, JR., Lu Wang, Lu Wang, Christopher C. Marvin, Ling C. Santora
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Abstract
Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.
Claims11
An antibody drug conjugate comprising:
- (a) an anti-TNFα antibody comprising a heavy chain set forth as SEQ ID NO:
- 3 and a light chain set forth as SEQ ID NO:
- 4;
- and
- (b) a glucocorticoid receptor agonist comprising a radical represented by the formula:
- wherein the antibody is conjugated to the glucocorticoid receptor agonist via a linker represented by the formula:
3 more elements
An antibody drug conjugate according to the formula:
- wherein A is adalimumab and n is 4.
An antibody drug conjugate according to the formula:
- wherein A is adalimumab and n is 2.
Dependencies are inferred from the claim text.