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US 2019/0167795 A1Published application
Conjugated lipomers and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsJames E. Dahlman, Avraham D. Schroeder, Daniel Griffith Anderson, Robert S. Langer, Christopher G. Levins
Life of this patent
Estimating the term…
Abstract
The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
Claims24
1-21. (canceled)
A conjugated lipomer of the Formula (IV):
- or salt thereof;
- wherein:
- each instance of L3 is independently:
- provided that the conjugated lipomer contains at least one group (vi), (vii) or (viii);
- each instance of R8 is independently hydrogen;
- acyl;
- silyl;
- sulfonyl;
- an amino protecting group;
- substituted or unsubstituted alkyl;
- substituted or unsubstituted alkenyl;
- substituted or unsubstituted alkynyl;
- substituted or unsubstituted heteroalkyl;
- substituted or unsubstituted heteroalkenyl;
- substituted or unsubstituted heteroalkynyl;
- substituted or unsubstituted carbocyclyl;
- substituted or unsubstituted heterocyclyl;
- substituted or unsubstituted aryl;
- substituted or unsubstituted heteroaryl;
- or
- provided the conjugated lipomer contains at least one group of the formula (iii′);
- each instance of R3 is independently substituted or unsubstituted alkyl;
- substituted or unsubstituted alkenyl;
- substituted or unsubstituted alkynyl;
- substituted or unsubstituted heteroalkyl;
- substituted or unsubstituted heteroalkenyl;
- substituted or unsubstituted heteroalkynyl;
- substituted or unsubstituted carbocyclyl;
- substituted or unsubstituted heterocyclyl;
- substituted or unsubstituted aryl;
- substituted or unsubstituted heteroaryl;
- or a hydrophilic polymer;
- each instance of R4 is independently hydrogen, acyl;
- silyl;
- a hydroxyl protecting group;
- substituted or unsubstituted alkyl;
- substituted or unsubstituted alkenyl;
- substituted or unsubstituted alkynyl;
- substituted or unsubstituted heteroalkyl;
- substituted or unsubstituted heteroalkenyl;
- substituted or unsubstituted heteroalkynyl;
- substituted or unsubstituted carbocyclyl;
- substituted or unsubstituted heterocyclyl;
- substituted or unsubstituted aryl;
- or substituted or unsubstituted heteroaryl;
- each instance of m and p is independently 0, 1 or 2;
- q is an integer 2, 3, or 4;
- and
- the dashed curved line, together with G and Y, is a covalent bond or a group of the formula:
- wherein s is 0, 1, or 2.
47 more elements
25-28. (canceled)
44-49. (canceled)
51-53. (canceled)
Dependencies are inferred from the claim text.