Anaerobic Blood Storage and Pathogen Inactivation Method
AssigneeHemanext Inc.
InventorsSamuel O. Sowemimo-Coker, Jeffrey Sutton, Tatsuro Yoshida
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Abstract
A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.
Claims33
A method for blood pathogen reduction having reduced hemolysis comprising:
- removing oxygen from a blood product to prepare an oxygen reduced blood product;
- reducing blood pathogens from said blood product comprising:
- adding riboflavin to a final concentration of between 40 to 60 μM and
- irradiating said riboflavin containing blood product with UV light between 265-400 nm.
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Oxygen reduced whole blood comprising whole blood collected in CPD, having between 40 to 60 μM riboflavin, having an oxygen saturation (SO2) of less than 25%, and having a pCO2 of 90 mmHg or less at 37° C., wherein said oxygen reduced whole blood has been irradiated with UV light between 265 to 400 nm.
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A method for blood pathogen reduction having reduced hemolysis comprising:
- removing oxygen from a blood product to prepare an oxygen reduced blood product;
- reducing blood pathogens from said oxygen reduced blood product comprising:
- adding S-303 to a final concentration of 0.2 mM;
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- adding glutathione (GSH) to a final concentration of between 2 to 20 mM.
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Oxygen reduced red blood cells having a final concentration of approximately 0.2 mM S-303, having an oxygen saturation (SO2) of less than 25%, and having a pCO2 of 90 mmHg or less at 37° C.
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A method for improving the efficacy of pathogen inactivation of S-303 in red blood cells comprising:
- removing oxygen from red blood cells to prepare an oxygen reduced blood product;
- adding S-303 to a final concentration of 0.2 mM;
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- adding glutathione (GSH) to a final concentration of between 2 to 20 mM.
Dependencies are inferred from the claim text.