Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines
AssigneeSeqirus UK Limited
InventorDerek O'Hagan
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Abstract
A split influenza virus vaccine is adjuvanted with an oil-in-water emulsion that contains free surfactant in its aqueous phase. The free surfactant can continue to exert a ‘splitting effect’ on the antigen, thereby disrupting any unsplit virions and/or virion aggregates that might be present.
Claims21
-34. (canceled)
A method of raising an immune response in a human comprising administering a composition to the human, wherein the composition comprises a split influenza virus antigen and a squalene-in-water emulsion adjuvant, and wherein the squalene-in-water emulsion adjuvant includes free surfactant in its aqueous phase.
A method of reducing antigen aggregate in an immunogenic vaccine comprising admixing a split influenza virus antigen with a squalene-in-water emulsion adjuvant to form the immunogenic vaccine, wherein the squalene-in-water emulsion adjuvant includes free surfactant in its aqueous phase.
Dependencies are inferred from the claim text.