Polypeptides binding to human complement c5

C5 binding polypeptide according to any preceding claim, wherein X3 is selected from I, L and V.

C5 binding polypeptide according to any preceding claim, wherein X4 is selected from A, D, E, K, L, Q and R.

C5 binding polypeptide according to any preceding claim, wherein X6 is W.

C5 binding polypeptide according to any preceding claim, wherein X7 is selected from A, D, N and T.

C5 binding polypeptide according to any preceding claim, wherein XII is selected from A, H, K, Q, R and S.

C5 binding polypeptide according to any preceding claim, wherein X16 is T.

C5 binding polypeptide according to any preceding claim, wherein X17 is selected from I and L.

C5 binding polypeptide according to any preceding claim, wherein X18 is selected from A, D, E, N, Q, S and T.

C5 binding polypeptide according to any preceding claim, wherein X21 is selected from I and L.

C5 binding polypeptide according to any preceding claim, wherein X25 is selected from E, H, N and T.

C5 binding polypeptide according to any preceding claim, wherein X26 is K.

C5 binding polypeptide according to any preceding claim, wherein X28 is selected from A, D, E, H, N, Q and S.

C5 binding polypeptide according to any preceding claim, wherein the amino acid sequence is selected from any one of SEQ ID NO:1-248.

C5 binding polypeptide according to any preceding claim, in which said C5 binding motif forms part of a three-helix bundle protein domain.

C5 binding polypeptide according to any preceding claim, which inhibits cleavage of C5.

C5 binding polypeptide according to any preceding claim, wherein the C5 binding polypeptide binds to C5 such that the KD value of the interaction is at most 1×10−6 M, such as at most 1×10−7 M, such as at most 1×10−8 M, such as at most 1×10−9 M.

C5 binding polypeptide according to any preceding claim, comprising further C terminal and/or N terminal amino acids that improves production, purification, stabilization in vivo or in vitro, coupling, or detection of the polypeptide.

C5 binding polypeptide according to any preceding claim in multimeric form, comprising at least two C5 binding polypeptide monomer units, the amino acid sequences of which may be the same or different.

C5 binding compound, comprising at least one C5 binding polypeptide according to any preceding claim;

• at least one albumin binding domain of streptococcal protein G, or a derivative thereof, and at least one linking moiety for linking said at least one domain or derivative thereof to the C or N terminal of said at least one C5 binding polypeptide.