Foxm1 modulators and uses thereof
AssigneeCity of Hope
InventorsJeremy Jones, Maya Otto-Duessel
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Abstract
Disclosed herein, inter alia, are FOXM1 modulators and methods for modulating the activity of androgen receptors in neuronal cells to treat various diseases, such as spinal-bulbar muscular atrophy, amyotrophic lateral sclerosis, and Alzheimer's disease.
Claims34
A method of treating spinal-bulbar muscular atrophy in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a FOXM1 inhibitor to treat the spinal-bulbar muscular atrophy.
A method of reducing the level of androgen receptor activity in a motor neuron, the method comprising contacting the motor neuron with an effective amount of a FOXM1 inhibitor to reduce the level of androgen receptor activity in the motor neuron.
A method of treating an androgen receptor activity-associated disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a FOXM1 inhibitor to treat the androgen receptor activity-associated disease.
A method of treating amyotrophic lateral sclerosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a FOXM1 inhibitor to treat the amyotrophic lateral sclerosis.
A method of treating Alzheimer's disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a FOXM1 inhibitor to treat the Alzheimer's disease.
The method of any one of embodiments 1 to 33, wherein the FOXM1 inhibitor does not inhibit androgen receptor activity in a muscle cell.
Dependencies are inferred from the claim text.