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US 2019/0167729 A1Published application
Oxygenated demineralized bone matrix for use in bone growth
AssigneesTheracell, Inc., Yissum Research Development Company of the Hebrew University of Jerusalem
InventorsFrank M. Phillips, Stephen H. Hochschuler, Dan Gazit, Gadi Pelled, Zulma Gazit
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Abstract
An improved composition for inducing bone growth is provided that is a combination of at least DBM and an oxygen carrier. Injection/implantation of a composition of DBM and an oxygen carrier (e.g. a perfluorocarbon) results in enhancement of bone formation compared to DBM alone.
Claims11
A method of inducing bone growth, comprising:
- implanting an effective amount of a composition for implantation within a patient for inducing bone growth at a target site in the patient, the composition consisting of:
- a perfluorocarbon in an amount of about 5% to about 60% (w/v);
- an emulsifier;
- and
- dem ineralized bone matrix (DBM),
- wherein the composition is free of cultured cells and is capable of inducing bone growth in the patient in the absence of cultured cells and the composition optionally consists of autologous bone chips, allograft bone chips, growth factors, fibrin, or collagen.
3 more elements
A method of inducing bone growth, consisting of:
- implanting an effective amount of a composition for implantation within a patient for inducing bone growth at a target site in the patient, the composition consisting of:
- a perfluorocarbon in an amount of about 5% to about 60% (w/v);
- an emulsifier;
- and
- dem ineralized bone matrix (DBM),
- wherein the composition is free of cultured cells and is capable of inducing bone growth in the patient in the absence of cultured cells and the composition optionally consists of autologous bone chips, allograft bone chips, growth factors, fibrin, or collagen.
3 more elements
Dependencies are inferred from the claim text.