Neuroprotective composition, preparation process thereof and medical uses thereof
AssigneeCaire Medical-Biotechnology International Co.
InventorsTe-Fu CHEN, Kuo-Chuan Wang
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Abstract
The invention relates to a neuroprotective composition derived from mesenchymal stem cells, especially a neuroprotective composition derived from the primary culture of dental pulp mesenchymal stem cells. The invention also relates to a process for preparing the neuroprotective composition, as well as the medical uses of the neuroprotective composition in the treatment of neurological diseases associated with neuronal damage, including subarachnoid hemorrhage and Parkinson's disease.
Claims9
A method for treating a neurological disorder associated with neuronal damage in a subject, comprising administering to said subject an effective amount of a neuroprotective composition to suppress neuronal damage;
- wherein the neuroprotective composition is obtainable by a process comprising the steps of:
- (i) culturing mesenchymal stem cells in a serum-free basal culture medium for at least 3 hours to obtain a cell culture;
- and
- (ii) processing the cell culture obtained in step (i) to obtain an aqueous fraction with a molecular weight of no more than about 5 kDa as the neuroprotective composition.
A method of inhibiting cerebral neuroinflammation in a subject in need thereof, comprising administering an effective amount of a neuroprotective composition, thereby inhibiting cerebral neuroinflammation in the subject;
- wherein the neuroprotective composition is obtainable by a process comprising the steps of:
- (i) culturing mesenchymal stem cells in a serum-free basal culture medium for at least 3 hours to obtain a cell culture;
- and
- (ii) processing the cell culture obtained in step (i) to obtain an aqueous fraction with a molecular weight of no more than about 5 kDa as the neuroprotective composition.
Dependencies are inferred from the claim text.