Compositions and methods for activating antigen presenting cells with chimeric poliovirus

A method for activating an antigen presenting cell, comprising:

• contacting in vitro an isolated antigen presenting cell with chimeric poliovirus or RNA encoding the chimeric poliovirus in an amount effective to activate the antigen presenting cell.

A method of performing immunotherapy, comprising:

• administering an activated antigen presenting cell that has been loaded with an antigen to an individual, wherein the activated antigen presenting cell is prepared by contacting an antigen presenting cell with chimeric poliovirus or RNA encoding the chimeric poliovirus in an amount effective to activate the antigen presenting cell.

A method of treating a disease comprising:

• administering to an individual an activated antigen presenting cell prepared by contacting an antigen presenting cell with (a) chimeric poliovirus or RNA encoding the chimeric poliovirus in an amount effective to activate the antigen presenting cell;
• and (b) an antigen.

A method for activating an antigen presenting cell, comprising:

• delivering a chimeric poliovirus or RNA encoding the chimeric poliovirus directly to mucosa or skin of a human in an amount effective to activate antigen presenting cells in the mucosa or skin.