Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
AssigneeYeda Research and Development Co. Ltd.
InventorsAlon CHEN, Eran HORNSTEIN, Orna ISSLER, Sharon HARAMATI, Naama VOLK
Life of this patent
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Abstract
microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.
Claims16
A method of treating a medical condition in which a low glutamate receptor level is therapeutically beneficial in a subject in need thereof, the method comprising administering to said subject miR-181 or a precursor thereof or expressing in a cell of said subject an exogenous polynucleotide encoding a miR-181 or a precursor thereof, thereby treating the medical condition.
An isolated cell comprising a nucleic acid construct expressing a miR-181 or a precursor thereof under a transcriptional control of a cis acting regulatory element.
A nucleic acid construct comprising a nucleic acid sequence encoding a miR-181 or a precursor thereof, said nucleic acid sequence being under a transcriptional control of a cis acting regulatory element.
A method of regulating an expression of a glutamate receptor gene in a neuroglia cell, the method comprising modulating an activity or expression of miR-181 or a precursor thereof in said neuroglia cell, thereby regulating the expression of the glutamate receptor gene.
Dependencies are inferred from the claim text.