Methods of Treating Conditions Involving Elevated Inflammatory Response
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsDaolin Tang, Timothy Billiar, Ling Zeng
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Abstract
A method of treating a patient having an elevated inflammatory response, such as an elevated Type I interferon response, is provided. The method can be used to treat sepsis. The method comprises administering to a patient having an elevated inflammatory response, an inhibitor of anaplastic lymphoma kinase (ALK inhibitors) or expression of ALK, in an amount effective to treat the elevated inflammatory response.
Claims22
A method of reducing a type I interferon (IFN) response in a patient having an inflammatory disease, comprising administering to the patient an amount of an ALK inhibitor or an inhibitor of ALK expression effective to reduce a type I interferon response in a patient.
A method of treating an inflammatory disease in a patient, comprising administering to the patient an amount of an ALK inhibitor or an inhibitor of ALK expression effective to treat the inflammatory disease in a patient.
A method of improving a patient's health-span or life-span, comprising administering to the patient an amount of an ALK inhibitor or an inhibitor of ALK expression effective to decrease a type I interferon (IFN) response or a stimulator of interferon genes (STING) response in a patient.
Dependencies are inferred from the claim text.