Compositions for oral administration of zoledronic acid or related compounds for treating disease

A method of treating arthritis comprising administering an oral dosage form containing a zoledronic acid, in an acid form or a pharmaceutically acceptable salt form, to a human being in need thereof, wherein the human being receives an amount of the zoledronic acid, within a period of one month, that is a molar equivalent of about 100 mg to about 300 mg of the acid form of zoledronic acid, wherein administering the zoledronic acid has a therapeutic effect on the human being, and the human being receives zoledronic acid no more often than once daily.