Methods of Treating Eye Pain With Aminophosphinic Derivatives

A method for treating or preventing eye pain in a subject in need thereof, the method comprising:

• administering a compound having formula (I) to the subject, the compound having formula (I) being:
• R1—NH—CH(R2)—P(═O)(OH)—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7
• wherein:
• R1 is:
• a hydrogen
• an (acyloxy)alkyl carbamate group —C(═O)—O—C(R)(R′)—OC(═O)—R″ wherein R and R′ are each independently a hydrogen, an alkyl group and R″ is an alkyl group;
• R2 is:
• a linear or branched, saturated or unsaturated hydrocarbon chain having from 1 to 6 carbon atoms;
• R3 and R4 are each independently:
• a hydrogen
• a phenyl or benzyl group, optionally substituted on the phenyl ring by:
• 1 to 5 halogen atoms;
• an OH, SH, OR″ or SR″ radical, R″ is an alkyl group;
• an amino group optionally mono- or di-substituted by a cyclic or linear aliphatic group having from 1 to 6 carbon atoms;
• a trifluoromethyl group;
• an aromatic or heteroaromatic group having 5 or 6 atoms;
• a heteroaromatic group having 5 or 6 atoms, containing 1 or 2 heteroatom(s) selected from oxygen, nitrogen or sulphur, wherein the sulphur and nitrogen atoms may be oxidized in S-oxide or N-oxide form;
• a methylene substituted by an aromatic or saturated heterocycle having 5 or 6 atoms, the heteroatom being an oxygen, a nitrogen or a sulphur, wherein the nitrogen and sulphur atoms may be oxidized in N-oxide or S-oxide form;
• R3 and R4 are not simultaneously a hydrogen atom;
• R5 and R6 are each independently:
• a hydrogen atom;
• a linear or branched, saturated or unsaturated hydrocarbon chain having from 1 to 6 carbon atoms;
• R7 is:
• a hydrogen;
• a CH2COOR′″ or CH(CH3)COOR′″ radical, R′″ being:
• a saturated hydrocarbon chain having from 1 to 6 carbon atoms, optionally substituted by a C1 to C3 alkoxy group;
• a C5 to C8 cycloalkyl group;
• a phenyl, benzyl or alkyl group;
• a CH(R)O—C(O)OR′ or CH(R)OC(O)R′ group wherein R and R′ are each independently a hydrogen or an alkyl group;
• or a pharmaceutically acceptable salt thereof.