US 2019/0167679 A1 · sGC STIMULATORS

sGC STIMULATORS

AssigneeIronwood Pharmaceuticals, Inc.

InventorsTakashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie

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Abstract

Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Claims15

Dependent claims

-169. (canceled)

Dependencies are inferred from the claim text.

Facts

Application

16/178,771Filed 2 Nov 2018

Priority

15 Mar 2013

Published

6 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings
A61K 31/517
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol

Family

Application61/790,637Us provisional application · filed 15 Mar 2013

Application61/914,915Us provisional application · filed 11 Dec 2013

Application14/775,954Division · filed 14 Sep 2015

Application15/245,697Continuation · filed 24 Aug 2016

Application16/178,771Continuation

Application15/245,697Division

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From the US filing history. Foreign family members aren’t listed.