Methods for improving resistance to skeletal muscle fatigue
AssigneeCytokinetics, Inc.
InventorsFady MALIK, Jeffrey R. JASPER, Adam KENNEDY, Darren T. HWEE
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Abstract
Provided are compounds, compositions and methods for improving resistance to skeletal muscle fatigue comprising administering an effective amount of a skeletal muscle troponin activator. Also provided are methods for improving resistance to fatigue, improving physical endurance, or reducing exercise intolerance in a subject suffering from a condition associated with muscle fatigue or weakness, such as heart failure.
Claims24
A method of improving resistance to skeletal muscle fatigue in a subject, the method comprising administering to the subject a therapeutically effective amount of a skeletal muscle troponin activator.
A method of improving resistance to fatigue in a skeletal muscle, the method comprising contacting the skeletal muscle with a skeletal muscle troponin activator.
7-13. (canceled)
A method for treating exercise intolerance in a patient suffering from heart failure comprising administering to the patient a therapeutically effective amount of a skeletal muscle troponin activator.
A method for improving physical endurance performance of a patient suffering from heart failure, comprising administering to the subject a therapeutically effective amount of a skeletal muscle troponin activator.
A method for increasing the function, activity, efficiency, sensitivity to calcium, or time to fatigue of skeletal muscle of a patient suffering from heart failure, comprising administering to the patient a therapeutically effective amount of a skeletal muscle troponin activator.
A method for improving skeletal muscle function of a patient suffering from heart failure, comprising administering to the patient a therapeutically effective amount of a skeletal muscle troponin activator.
25-26. (canceled)
28-34. (canceled)
Dependencies are inferred from the claim text.