Methods and compositions for appetite control and weight management
AssigneeShanghai Yao Yuan Biotechnology Co., Ltd.
InventorsJieqing FAN, Yan LIU, Cong XU
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Abstract
The present invention provides methods and compositions for modulation of appetite, or for treatment of an appetite disorder or a metabolic disorder such as obesity or overweight, comprising a DEG/ENaC receptor modulator. The present invention also provides methods for identifying an agent for appetite modulation and/or weight management.
Claims25
(canceled)
A method of regulating appetite, or treating or preventing an appetite disorder or a metabolic disorder, in a subject, comprising administering to the subject a therapeutically effective amount of a modulator capable of modulating the activity of a DEG/ENaC receptor.
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A method for identifying an agent for appetite modulation and/or weight management, said method comprising the steps of:
- providing an assay to determine modulation of expression or activity of an DEG/ENaC receptor;
- introducing to said assay a compound suspected of being an DEG/ENaC modulator;
- and
- determining whether DEG/ENaC modulation occurs,
- wherein the agent that modulates the level of expression or activity of the DEG/ENaC ion channel is a candidate for modulation of appetite or management of weight.
(canceled)
A pharmaceutical composition for modulation of appetite, or for treatment of an appetite disorder or a metabolic disorder, comprising:
- a DEG/ENaC receptor modulator and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.