Abuse Resistant Pharmaceutical Compositions

A method of preparing an oral dosage form comprising a population of immediate release beads comprising an opioid and a population of gelling agent-containing beads comprising polyethylene oxide and a permeable or semi-permeable coating polymer, the method comprising the steps of:

• a) independently preparing a solution comprising an opioid selected from the group consisting of benzylmorphine, bezitramide, buprenorphine, butorphanol, carfentanil, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diacetylmorphine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, diphenoxylate, dioxaphetyl butyrate, diprenorphine, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, etorphine, dihydroetorphine, fentanyl, hydrocodone, hydromorphone, β-hydroxy-3-methylfentanyl, hydroxypethidine, isomethadone, ketobemidone, levo-α-acetylmethadol, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalmefene, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, nalbuphene, normorphine, norpipanone, o-methylnaltrexone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, pethidine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, propheptazine, promedol, properidine, propoxyphene, remifentanil, sufentanil, tilidine, and tramadol, or pharmaceutically acceptable salts thereof;
• b) applying sufficient amounts of the solution of step a) onto sufficient amounts of sugar spheres to produce an immediate release population of the opioid;
• c) independently forming a binder solution by dissolving a binder in a solvent mixture comprising alcohol and water;
• d) applying the binder solution and a sufficient amount of polyethylene oxide powder onto sufficient amounts of sugar spheres to produce polyethylene oxide layered sugar spheres;
• e) independently forming a coating polymer mixture by mixing the permeable or semi-permeable polymer in a solvent mixture comprising alcohol, acetone and water;
• f) applying the coating polymer mixture onto polyethylene oxide layered sugar spheres of step e) to form a population of polymeric coated polyethylene oxide layered sugar spheres;
• and
• g) mixing the immediate release beads and the polymeric coated polyethylene oxide layered sugar spheres in different proportions to form the dosage form.