Ccr6 compounds

A compound having formula (I):

• or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide or rotamer thereof,
• wherein
• A is a carboxylic acid moiety or a carboxylic acid isostere;
• ring vertices a, b, c and d are independently selected from N, CH and C(R1);
• each R1 is independently selected from the group consisting of halogen, CN, —SF5, C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 haloalkyl, —ORa, —SRa, —CORa, —NRaRb, and 5- or 6-membered heteroaryl, wherein the alkyl portions of R1 are optionally further substituted with 1-3 Ra;
• and optionally, adjacent R1 members are connected to form an additional 5- or 6-membered ring which is saturated or unsaturated having ring vertices selected from C, O, S and N, wherein the additional 5- or 6-membered ring is optionally substituted with one or two members selected from the group consisting of halogen, hydroxyl, C1-4 alkyl, C1-4 alkoxy and C1-4 haloalkyl;
• the subscript m is an integer of from 0 to 2;
• the subscript n is an integer of from 0 to 3;
• each R2 and R3 is independently selected from the group consisting of halogen, CN, C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 haloalkyl, aryl, —ORa, —NRaRb and —N(Ra)—C1-C4 alkylene-ORb, and wherein the alkyl or aryl portions of R2 and R3 are optionally further substituted with 1-3 Ra;
• Ar is a 5- or 6-membered aromatic or heteroaromatic ring that is optionally substituted with from 1 to 5 R4 substituents independently selected from the group consisting of halogen, CN, —SF5, C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, —ORa, —NRaRb, 5- or 6-membered heteroaryl, and 3-, 4-, 5- or 6-membered heterocycloalkane wherein the heteroatoms present as ring vertices of the heteroaryl and heterocycloalkane rings are selected from N, O and S, and wherein the alkyl, cycloalkyl, aryl, heteroaryl and hetereocycloalkane portions of R4 are optionally further substituted with 1-3 Ra;
• each Ra and Rb is independently selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl, amino, C1-8 alkylamino, and di C1-8 alkylamino, or when attached to a nitrogen atom are optionally combined to form a 4- to 7-membered saturated ring, which is optionally substituted with oxo.