Methods of treating pancreatic cancer

A method of limiting over-expression of oncogenes, activating tumor suppressor genes, or regulating signaling proteins comprising administering to a patient in need thereof an effective amount of a compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is halogen or C1-6 alkyl;
• R2 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, or —CN;
• R3 is hydrogen, halogen, or C1-6 alkyl;
• R4 is hydrogen, halogen, or C1-6 alkyl;
• each R5 is independently C1-6 alkyl, —OH, or —NH2;
• n is 0, 1, 2, or 3;
• and
• each of A1, A2, and A3 is —CH— or —N—, where at least one of A1, A2, or A3 is —N—.