Topical rapamycin therapy
AssigneeBoard of Regents, The University of Texas System
InventorsMary Kay KOENIG, Hope NORTHRUP, Adelaide A. HEBERT
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Abstract
A topical composition containing rapamycin and an alcohol-free carrier is used to deliver rapamycin to skin cells while preventing systemic absorption, allowing for safe and effective treatment of various skin conditions, including angiofibromas that arise from conditions such as Tuberous Sclerosis Complex (TSC).
Claims18
A composition for use in treating facial angiofibromas, or other skin lesions, in a patient in need thereof, the composition comprising rapamycin in an amount of from 0.1% to 5% by weight, a liquid glycol, and a dermatologically acceptable carrier, wherein the composition is free of alcohol.
A composition for use in treating facial angiofibromas in a patient in need thereof, the composition comprising rapamycin in an amount of from greater than 2% up to 5%, or from about 2.5% or 3% up to about 5% by weight, a liquid glycol in an amount of from 1-8% by weight, and a dermatologically acceptable carrier, wherein the composition is free of added alcohol, acetone, and polyvinylidene fluoride, and all weight percentages are based on the total weight of the composition.
Dependencies are inferred from the claim text.