Retinal derivatives and methods for the use thereof for the treatment of visual disorders
AssigneeUniversity of Washington
InventorsKrzysztof Palczewski, Matthew Batten
Life of this patent
Estimating the term…
Abstract
Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
Claims18
A retinyl ester selected from the group consisting of a 9-cis-retinyl ester and an 11-cis-retinyl ester, wherein the ester substituent comprises a carboxylate radical of a C3 to C22 polycarboxylic acid, with the proviso that the ester substituent is not tartrate.
A method of restoring photoreceptor function in a mammal, comprising administering to a mammalian subject having an endogenous retinoid deficiency an effective amount of a synthetic retinal derivative, wherein the synthetic retinal derivative is converted into a retinal capable of forming a functional opsin/retinal complex,
- wherein the synthetic retinal derivative is a 9-cis-retinyl ester, an 11-cis-retinyl ester, or a combination thereof;
- wherein the ester substituent comprises a carboxylate radical of a C1-C10 monocarboxylic acid or a C2 to C22 polycarboxylic acid.
A method of ameliorating loss of photoreceptor function in a mammal, comprising:
- administering an effective amount of a synthetic retinal derivative to the vertebrate eye, wherein the synthetic retinal derivative is converted into a retinal capable of forming a functional opsin/retinal complex,
- wherein the synthetic retinal derivative is a 9-cis-retinyl, an 11-cis-retinyl ester, or a combination thereof;
- wherein the ester substituent comprises a carboxylate radical of a C1-C10 monocarboxylic acid or a C2 to C22 polycarboxylic acid.
Dependencies are inferred from the claim text.