Pharmaceutical formulation for oral administration with controlled dissolution rate comprising sustained-release pellets containing tamsulosin hydrochloride

A hard capsule composite formulation containing tamsulosin hydrochloride comprising:

• (A) tamsulosin hydrochloride-containing sustained-release pellets, each pellet comprising (i) tamsulosin hydrochloride, (ii) hydroxypropyl methylcellulose (HPMC), (iii) an acid-resistant acrylic polymer, and (iv) two or more kinds of insoluble diluent;
• and
• (B) a pharmaceutical composition physically separated from the tamsulosin hydrochloride-containing sustained-release pellets, the pharmaceutical composition comprising one or more different pharmaceutically active ingredients and a pharmaceutically acceptable carrier.