Compositions of pharmaceutical product with ingestible event marker
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsMark ZDEBLICK, Markus CHRISTEN, Nikhil PARGAONKAR, Nikolaus LEIST, Kurt SCHEINPFLUG, Patricia JOHNSON, Benedict COSTELLO
Life of this patent
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Abstract
In some embodiments, a composition of matter includes aripiprazole, a metal selected from the group consisting of magnesium, zinc, sodium, lithium, iron, or alloys thereof, or combinations thereof and a copper salt selected from the group consisting of copper iodide, copper chloride, copper bromide, copper sulfate, copper formate, or combinations thereof.
Claims52
A composition of matter for the ingestible administration of aripiprazole, the composition comprising:
- aripiprazole;
- a metal selected from the group consisting of magnesium, zinc, sodium, lithium, iron, or alloys thereof, or combinations thereof;
- and
- a copper salt selected from the group consisting of copper iodide, copper chloride, copper bromide, copper sulfate, copper formate, or combinations thereof.
An apparatus, comprising:
- an active agent comprising aripiprazole;
- a substrate with a first surface and a second surface;
- a partial power source comprising
- a first material provided on the first surface of the substrate, wherein the first material is selected from the group consisting of magnesium, zinc, sodium, lithium, iron, and alloys thereof, an intercalation compound, vanadium oxide, manganese oxide, and combinations thereof, and
- a second material provided on the second surface of the substrate, wherein the second material is selected from copper iodide, copper chloride, copper bromide, copper sulfate, copper formate, iron(III) phosphate, iron(III) pyrophosphate, oxygen, hydrogen, vanadium oxide, manganese oxide, and combinations thereof,
- wherein the partial power source is configured to generate power upon contact of the first material and the second material with a fluid;
- and
- a control unit electronically coupled with the partial power source, wherein the control unit is configured to be activated by receiving the power from the partial power source and to encode information in a current flow through the fluid.
A composition of matter for the ingestible administration of aripiprazole, the composition comprising:
- aripiprazole;
- and
- silicon having a mass equivalent to a silicon substrate having dimensions of between 0.2×0.2×0.2 mm (0.008 mm3) and 0.3×0.3×0.3 mm (0.027 mm3).
Dependencies are inferred from the claim text.