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US 2019/0167574 A1Published application
Injectable long-acting local anesthetic semi-solid gel formulations
AssigneeMira Pharma Corporation
InventorsHui Rong Shen, Na Gan
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Abstract
What is disclosed is a controlled release pharmaceutical composition comprising a biocompatible and bioerodible semi-solid gel comprising a triglyceride of ricinoleic acid, a gelling agent, bupivacaine and, optionally, a corticosteroid, an analgesic, or an anti-inflammatory agent.
Claims22
A pharmaceutical formulation, comprising
- (A) a glyceride mixture comprising
- (i) triglyceride of ricinoleic acid;
- and
- (ii) glycerides selected from the group consisting of (a) a mixture of C12 to C18 triglycerides (SUP DM) (b) a mixture of C8 to C18 triglycerides (G43/01);
- (c) a mixtures of hydrogenated coco-glycerides (WIT E85 and WIT E76);
- and (d) a mixture of C10 to C18 triglycerides (SUP D);
- or other solid glycerides with a melting point between 37° C. and 75° C.;
- wherein the ratio (i):(ii), is 10:1 to 6:3 (w:w);
- and
- (B) active agents comprising (i) a therapeutically effective amount of bupivacaine to provide analgesia for at least two days;
- and, optionally, (ii) a corticosteroid, an analgesic or an anti-inflammatory agent;
- wherein the active agents are solubilized in the glyceride mixture at a concentration of 0.01-60 wt %;
- and wherein the pharmaceutical composition is a semi-solid gel which is biocompatible, bioerodible, homogeneous, and a single phase;
- and wherein the pharmaceutical composition consists of a semi-solid gel with a viscosity of 50-2000 cPs at 30° C.
11 more elements
Dependencies are inferred from the claim text.