Drug delivery systems and applications
AssigneeIncept, LLC
InventorsPeter Jarrett, Rami El-Hayek, Amarpreet S. Sawhney, Sarah Guedez
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Abstract
Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.
Claims49
A medical material comprising
- a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a low water soluble lipophilic compound and further comprise a therapeutic agent that comprises a protein having a secondary and/or a tertiary structure, wherein the lipophilic particles are solid at 20° C. and have a low water solubility in physiological saline at physiological temperature, with the protein being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.
A process of making a medical material comprising
- coating a protein powder with a low water soluble lipophilic compound to make particles,
- dispersing the particles in a medical hydrogel implant,
- with the protein having a secondary and/or a tertiary structure and being released from the microparticles and the medical material in a conformation that is substantially free of denaturation as measurable by enzyme-linked immunosorbent assay and isoelectric focusing.
A method of delivering a therapeutic agent to a patient comprising placing a hydrogel in a patient that comprises a collection of particles that comprise a low water soluble lipophilic compound and a therapeutic agent, with the agent being released into the patient.
A kit comprising an applicator, a hydrogel precursor, and lipophilic particles that comprise a low water soluble lipophilic compound and a therapeutic agent, wherein the lipophilic particles are solid at 20° C. and have a low water solubility in physiological saline at physiological temperature, with the applicator being adapted to deliver a mixture of the particles and the precursor into an eye.
Dependencies are inferred from the claim text.