Reinforced Bone Scaffold
AssigneeMarquette University
InventorsLobat Tayebi, Morteza Rasoulianboroujeni
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Abstract
Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.
Claims21
A scaffold for use in bone tissue engineering, the scaffold comprising:
- a skeleton constructed to form a three-dimensional shape, the skeleton constructed of a first material and having a first rate of biodegradation;
- a host component filling the three-dimensional shape formed by the skeleton, the host component constructed of a second material and having a second rate of biodegradation, wherein the first rate of biodegradation is slower than the second rate of biodegradation.
A method of preparing a scaffold for use in bone tissue engineering, the method comprising:
- obtaining a 3D model of a treatment area of a patient;
- determining a desired degradability of the scaffold based upon the patient and treatment area;
- selecting at least one skeleton characteristic and at least one host component characteristic to achieve desired degradability;
- digitally designing skeleton to fit the treatment area;
- manufacturing the skeleton with the at least one skeleton characteristic;
- and
- filling the skeleton with a host component having the at least one host component characteristic.
Dependencies are inferred from the claim text.