Method and apparatus for estimating temperature in a body

A non-transitory computer-readable storage medium storing a set of instructions for planning an application of heat to an associated body part of an associated patient to obtain a desired spatial distribution of heat in treatment and non-treatment target tissues of the associated body part of the associated patient, when executed by one or more processors, causing the one or more processors to perform the steps comprising:

• obtaining imaging information of an image obtained of the associated body part of the associated patient;
• identifying by the processing unit, from the imaging information of the associated body part of the associated patient, patient image data, the patient image data being representative of a set of patient tissue parameters of the associated body part of the associated patient and physical features of the associated body part of the associated patient comprising an extravascular-extracellular space (EES) of the associated body part of the associated patient;
• retrieving from the database a reference model of a temperature transport mechanism or a temperature distribution mechanism in a reference body part of the reference model, the reference model comprising data representative of tissue parameters of a model generic patient other than the associated patient and physical features of the model generic patient other than the associated patient;
• generating by the processing unit, from the reference model and the imaging information of the associated body part of the associated patient, an individualized patient model by registering the data representative of the tissue parameters and the physical features of the model generic patient other than the associated patient of the reference model with the patient image data representative of the patient tissue parameters and the physical features of the associated body part of the associated patient, the individualized patient model modeling one or more of a temperature transport mechanism in the associated body part of the associated patient and/or a temperature distribution mechanism in the associated body part of the associated patient;
• determining, by the processing unit based on simulating applying heat applied to specific spatial destinations in the individualized patient model, a simulated spatial heat distribution of the simulated heat in the treatment target tissue and in the non-treatment target tissue of the associated body part of the associated patient;
• and
• storing the simulated heat treatment in the database as the heat treatment plan in accordance with the processing unit determining that:
• the simulated spatial heat distribution of the applied simulated heat in the treatment target tissue matches the desired spatial distribution of heat in the treatment target tissue of the associated body part of the associated patient;
• and
• the simulated spatial heat distribution of the applied simulated heat in the non-treatment target tissue matches the desired spatial distribution of heat in the non-treatment target tissue of the associated body part of the associated patient.