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US 2019/0166810 A1Published application
Human liver chimeric non-human animal with deficient p450 oxidoreductase and methods of using same
AssigneeBaylor College of Medicine
InventorsKarl-Dimiter BISSIG, Maria de las Mercedes Barzi DIEGUEZ, Peter Francis PANKOWICZ
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Abstract
The present disclosure provides a chimeric non-human animal comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to screening and identifying metabolites for any type of drugs, typically small molecule drugs, which might affect human liver functions and any other bodily function.
Claims32
A method for preparing a chimeric non-human animal comprising human hepatocytes, the method comprising:
- (a) providing a non-human animal comprising a reduction or deletion of NADPH-P450 oxidoreductase (Por) gene resulting in reduced or absent expression of Por protein;
- and
- (b) transplanting human hepatocytes into the non-human animal.
Dependencies are inferred from the claim text.