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US 2019/0161529 A1Published application
Compositions and methods for neurological diseases
AssigneeCoda Biotherapeutics, Inc.
InventorsKenneth P. GREENBERG, Orion KEIFER, Jr., Stefanie MAKINSON, Anthony LAU
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Abstract
Compositions and methods are provided for modulating the activity of cells using engineered receptors, polynucleotide encoded engineered receptors, and gene therapy vectors comprising polynucleotides encoding engineered receptors. These compositions and methods find particular use in modulating the activity of neurons, for example in the treatment of disease or in the study of neuronal circuits.
Claims29
An engineered receptor, wherein the engineered receptor is a chimeric ligand gated ion channel (LGIC) receptor and comprises
- (a) a ligand binding domain derived from a first wild type Cys-loop LGIC receptor,
- (b) a Cys-loop domain from a second wild-type Cys-loop LGIC receptor;
- and
- (c) an ion pore domain derived from the second wild type Cys-loop LGIC receptor.
1 more element
Dependencies are inferred from the claim text.